A fast transform for brain connectivity difference evaluation.

M. Zanin, I. Ivanoska, B. Güntekin, G. Yener, T. Loncar-Turukalo, N. Jakovljevic, O. Sveljo & Papo D.

Neuroinformatics (2021) https://doi.org/10.1007/s12021-021-09518-7

Anatomical and dynamical connectivity are essential to healthy brain function. However, quantifying variations in connectivity across conditions or between patient populations and appraising their functional significance are highly non-trivial tasks. Here we show that link ranking differences induce specific geometries in a convenient auxiliary space that are often easily recognizable at mere eye inspection. Link ranking can also provide fast and reliable criteria for network reconstruction parameters for which no theoretical guideline has been proposed.

[Read more in Neuroinformatics]

Keywords: Functional brain connectivity; complex networks; link difference ranking; Alzheimer’s disease; Schizophrenia

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Principles and open questions in functional brain network reconstruction

O. Korhonen, M. Zanin & D. Papo

Human Brain Mapping 42:3680–3711 (2021) .

Graph theory is now becoming a standard tool in system-level neuroscience. However, endowing observed brain anatomy and dynamics with a complex network representation involves often covert theoretical assumptions and methodological choices which affect the way networks are reconstructed from experimental data, and ultimately the resulting network properties and their interpretation. Here, we review some fundamental conceptual underpinnings and technical issues associated with brain network reconstruction, and discuss how their mutual influence concurs in clarifying the organization of brain function.

[Read more in Human Brain Mapping]